For Physicians: Active Studies
We sincerely thank our clinical teams for their dedication and partnership in advancing pediatric critical care research. Please find below additional resources highlighting our active research studies, including study summaries, enrollment criteria, and relevant contact information to assist with patient identification and enrollment.
Please note that P-ICECAP and SHIPSS have time sensitive enrollment windows.
Interventional Studies
Focus: RSV
Type: Interventional
Procedure: Azithromycin vs Placebo, Blood Sampling
Inclusion: >1 wk <2 y; RSV+, high respiratory support
Focus: Cardiac Arrest
Type: Interventional
Procedure: Duration on Cooling Blanket
Inclusion: OHCA, >2 days <18 y; chest compressions >2 min (<60 min); randomize within 6 hrs of ROSC
Focus: Sepsis-induced MODS
Type: Interventional
Procedure: Anakinra vs Placebo, Immune phenotyping
Inclusion: >4 mo <18 y; onset of >2 new organ dysfunctions; infection suspected
Focus: Septic Shock
Type: Interventional
Procedure: Hydrocortisone vs Placebo, Blood Sampling
Inclusion: >42 wks <17.5 y; >2 vasoactives OR 0.1 NE/Epi, 12 hr window
Observational Studies
Focus: Immune Response in MODS
Type: Observational
Procedure: Blood Sampling
Inclusion: 40 wks to <18 y; 2+ organ dysfunction; qualifying antibiotic
Focus: Lung recovery on ECMO
Type: Observational
Procedure: Survey & Questionnaires
Inclusion: >2 wks <18 y; ECMO; <240 hrs ventilation
Focus: LRTIs & respiratory failure
Type: Observational
Procedure: Tracheal aspirate, nasal swabs, blood
Inclusion: Mech. ventilation >24 hrs for respiratory failure
Focus: COVID-19, MIS-C, immune response
Type: Observational
Procedure: Respiratory & blood sampling
Inclusion: Hospitalized ≤21 y with COVID-19 or MIS-C
Focus: Pulse oximetry & skin pigmentation
Type: Observational
Procedure: Simultaneous SpO₂/SaO₂, pigmentation assessment
Inclusion: ≤21 y with arterial access
Focus: Influenza
Type: Observational
Procedure: Blood Sampling
Inclusion: <21 y; Influenza+
Focus: Myeloid hyperinflammation in SA-AKI
Type: Observational
Procedure: QUELIMMUNE device during CKRT
Inclusion: ≥10 kg, ≤22 y with SA-AKI on CKRT
Focus: Septic Shock
Type: Observational
Procedure: Blood Sampling
Inclusion: <18 y, suspected sepsis, vasopressors; antimicrobials
What Qualifies as MODS?
Multi-Organ Dysfunction Syndrome (MODS) is defined as clinically significant dysfunction in two or more organ systems, based on the modified Proulx criteria. Click each organ system below to explore the qualifying thresholds.
Respiratory Dysfunction
- RR >90/min (<1 yr) or >70/min (>1 yr)
- PaO₂ <40 mmHg (5.3 kPa) without cyanotic congenital heart disease
- PCO₂ >65 mmHg with pH <7.32
- PaO₂/FiO₂ <200 or SaO₂/FiO₂ ≤220
- Mechanical ventilation >24 hrs (including HFNC ≥1 L/kg/min or >30 L/min, NIV, ECMO)
- pH <7.2 with normal PaCO₂
Cardiovascular Dysfunction
- SBP <40 mmHg (<1 yr) or <50 mmHg (>1 yr)
- HR <50 or >220 (<1 yr); HR <40 or >200 (>1 yr)
- Cardiac arrest
- Continuous vasoactive infusion (excluding dopamine <5 mcg/kg/min)
- VAD or ECMO support
Renal Dysfunction
- Creatinine ≥177 μmol/L (≥2.0 mg/dL) without pre-existing renal disease
- BUN >36 mmol/L (>100 mg/dL)
- Dialysis or hemofiltration (not including baseline dialysis patients)
Neurological Dysfunction
- Fixed, dilated pupils (>3 mm)
- GCS <5 without neuromuscular blockade
Hematological Dysfunction
- Hemoglobin <50 g/L (<5 g/dL)
- >20 g/L hemoglobin drop in 24 hours
- Platelets <20 × 10⁹/L
- DIC: PT >20 sec or aPTT >60 sec (without anticoagulation)
- WBC <3 × 10⁹/L
Hepatic Dysfunction
- Total bilirubin >60 μmol/L (>3 mg/dL)
Gastrointestinal Dysfunction
- GI bleed requiring transfusion or associated with hypotension
- Gastric or duodenal surgery
- Death due to gastrointestinal cause
For inquiries regarding patient eligibility, study protocols, or procedural details, please contact:
Oakland
Mingying Yeoh
[email protected]