For Physicians: Active Studies
We sincerely thank our clinical teams for their dedication and partnership in advancing pediatric critical care research. Please find below additional resources highlighting our active research studies, including study summaries, enrollment criteria, and relevant contact information to assist with patient identification and enrollment.
Please note that P-ICECAP and SHIPSS have time sensitive enrollment windows.
Interventional Studies
Focus: RSV
Type: Interventional
Procedure: Azithromycin vs Placebo, Blood Sampling
Inclusion: > 1wk <2y; RSV+, high respiratory support
Focus: Cardiac Arrest
Type: Interventional
Procedure: Duration on Cooling Blanket
Inclusion: Out-of-hospital CA, >2 days <18y; chest compressions >2min, <60 min; randomization within 6hrs of ROSC
Focus: Sepsis-induced MODS
Type: Interventional
Procedure: Anakinra vs Placebo, Immune phenotyping
Inclusion: >4mo <18yo; onset of >2 new organ dysfxn; suspicion of infection
Focus: Septic Shock
Type: Interventional
Procedure: Hydrocortisone vs Placebo, Blood Sampling
Inclusion: >42 wks <17.5 yo; >2 vasoactives OR 0.1 NE or EPi, 12 hr enrollment window
Observational Studies
Focus: Immune Response in MODS
Type: Observational
Procedure: Blood Sampling
Inclusion: 40wks to <18y; 2+ organ dysfunction; qualifying antibiotic
Focus: Lung recovery on ECMO
Type: Observational
Procedure: Survey & Questionnaires
Inclusion: >2wks <18yo; ECMO; <240 hrs of ventilation
Focus: Lower respiratory tract infections and respiratory failure
Type: Observational
Procedure: Tracheal aspirate sampling, nasal swabs, blood draws,
Inclusion: Mechanical ventilation for >24 hours due to respiratory failure
Focus: COVID-19, MIS-C, and immune response
Type: Observational
Procedure: Respiratory and blood sampling
Inclusion: Hospitalized patients ≤21 years with COVID-19 or MIS-C
Focus: Pulse oximetry accuracy across skin pigmentation
Type: Observational
Procedure: Simultaneous SpO₂ and SaO₂ measurements, skin pigmentation assessment
Inclusion: Children ≤21 years with arterial access
Focus: Influenza
Type: Observational
Procedure: Blood Sampling
Inclusion: <21y; Influenza+
Focus: Myeloid hyperinflammation in sepsis-associated AKI
Type: Observational
Procedure: Use of QUELIMMUNE device during CKRT
Inclusion: Patients ≥10kg, ≤22 years with AKI due to sepsis on CKRT
Focus: Septic Shock
Type: Observational
Procedure: Blood Sampling
Inclusion: <18y, suspected sepsis, vasopressors for shock; antimicrobial therapy
What Qualifies as MODS?
MODS is defined by dysfunction in two or more organ systems as specified by the modified Proulx criteria. Click each organ system below to view the qualifying criteria.
Respiratory Dysfunction
- Respiratory rate >90/min (<1 yr) or >70/min (>1 yr)
- PaO₂ <40 mmHg (5.3 kPa) without cyanotic congenital heart disease
- PCO₂ >65 mmHg with pH <7.32
- PaO₂/FiO₂ <200 or SaO₂/FiO₂ ≤220
- Mechanical ventilation >24 hrs (including HFNC ≥1 L/kg/min or >30 L/min, NIV, ECMO)
- pH <7.2 with normal PaCO₂
Cardiovascular Dysfunction
- SBP <40 mmHg (<1 yr) or <50 mmHg (>1 yr)
- HR <50 or >220 (<1 yr), <40 or >200 (>1 yr)
- Cardiac arrest
- Continuous vasoactive drug infusion (excluding dopamine <5 mcg/kg/min)
- Ventricular assist device or ECMO
Renal Dysfunction
- Serum creatinine ≥177 μmol/L (≥2.0 mg/dL) without pre-existing renal disease
- BUN >36 mmol/L (>100 mg/dL)
- Dialysis or hemofiltration (except baseline dialysis patients)
Neurological Dysfunction
- Fixed, dilated pupils (>3 mm)
- GCS <5 without neuromuscular blockade
Hematological Dysfunction
- Hemoglobin <50 g/L (<5 g/dL)
- Drop in hemoglobin >20 g/L in 24 hours
- Platelet count <20 x 10⁹/L
- DIC: PT >20s or aPTT >60s without anticoagulation
- WBC count <3 x 10⁹/L
Hepatic Dysfunction
- Total bilirubin >60 μmol/L (>3 mg/dL)
Gastrointestinal Dysfunction
- GI bleed with transfusion or hypotension ascribed to GI bleed
- Gastric/duodenal surgery
- Death due to GI cause
For inquiries regarding patient eligibility, study protocols, or procedural details, please contact: